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What is Tapentadol? Tapentadolis a prescription pain medication used to treat moderate to severe pain. It is an opioid analgesic that works by binding to certain receptors in the brain and spinal cord to block pain signals. It is available in both immediate-release and extended-release formulations, and is typically taken orally. How does it work?Tapentadol works by binding to specific receptors in the brain and spinal cord called mu-opioid receptors. By binding to these receptors, it reduces the transmission of pain signals in... more